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Arens, principal investigator on the study. Jayaram K. Udupa , Ph.D., professor of Radiologic Science in Radiology, Perelman School of Medicine, The University of Pennsylvania, and David M. Wootton , Ph.D., professor of Mechanical Engineering, C. V. Starr Distinguished Professor of Engineering, and associate director, Maurice Kanbar Center for Biomedical Engineering , Albert Nerken School of Engineering at The Cooper Union for the Advancement of Science and Art, will bring their unique expertise in magnetic resonance imaging (MRI) analysis and bioengineering to take a novel approach to understanding the complexities of this sleep disorder. imp sourceUsing biomarkers such as oxygen saturation and heart rate obtained during sleep studies, multi-dimensional airway images from MRI, and complex computer modeling to simulate air flow and pressure through the respiratory cycle, the team will create a biomechanical model that will enable them to study the mechanics of the upper airway during periods of both wakefulness and sleep in obese teenage children at risk for OSAS. The five year observational study will enroll 140 adolescents between 12 and 17-years-old. Over a two year period researchers will analyze patients breathing while both awake and asleep. They will also evaluate the various treatment options for OSAS to better understand why some obese children have OSAS, while others do not, and examine the reasons why only some patients have success with certain OSAS therapies. Dr.
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