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The remaining four gene groups in common among the brain tissue from all three sets of those with mental illness were “turned down” compared to the controls, the team reported. Two of the gene sets have clear roles in how the brain’s neurons send and receive messages to neighboring cells, with one set making up general neuron genes and the other specific to GABA, a neurotransmitter used as the actual messenger between neurons. Another gene group is believed to help operate the ways in which the immune system mounts a response to foreign — and potentially threatening — antigens, biological molecules presented by a virus, bacterium or parasite. The researchers say that disruption of the immune system is a hallmark feature long observed in some people with mental illness, particularly in schizophrenia and, to a lesser extent, in bipolar disorder. The fourth gene set included genetic components involved in endocytosis — the process used to engulf biological molecules outside the cell and bring them inside. When neurons suck up neurotransmitters for recycling after they have been sent or received as a message, they use endocytosis. Endocytosis also plays a role in the immune system’s process of engulfing and disposing of germs. Sabunciyan says the research team plans to study these changes in induced pluripotent stem cells derived from patients, which also show an increase in ribosomal gene expression. According to the National Institute of Mental Health, approximately 1 percent of adults develop schizophrenia, about 2.5 percent have bipolar disorder and almost 7 percent of people develop major depression over their lifetimes. ### Robert Yolken, M.D.
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